Jesse Levey

What Jesse talked about

Jesse Levey discussed longevity and health strategy, arguing against both overly individualized biohacking advice and one-size-fits-all dogma. He made the case that a small set of interventions—reducing alcohol, prioritizing sleep, and tracking VO2 max—benefit nearly everyone, while diet is often overemphasized relative to these other levers.

He talked through specific tools for assessing health, including DEXA scans for measuring visceral fat and muscle mass beyond what body fat percentage or BMI can show, and VO2 max as a predictor of both lifespan and healthspan. He also addressed newer biological age clocks and telomere testing, arguing they remain promising but not yet validated enough to drive decisions, in contrast to more established markers like metabolic health.

The show

The Total Entrepreneur is a weekly conversation with founders, researchers, and health experts about what actually moves entrepreneurial performance across mind, body, spirit, and business.